MD-Paedigree, which stands for Model-Driven European Paediatric Digital Repository, is a clinically-led VPH project which provides decision support to medical professionals wherever they treat their patients. Through disease simulations, sometimes requiring the availability of high performance and supercomputer resources, MD-Paedigree improves the diagnostic precision of paediatricians and offer child-specific treatment choices for Europe’s children. Using MD-Paedigree, physicians will be able to select highly individualised treatment options, and receive on-the-spot support in predicting treatment outcome based on each patient’s personal medical data. MD-Paedigree focuses on four paediatric disease areas: Cardiomyopathies, Obesity-related Cardiovascular Disease, Juvenile Idiopathic Arthritis, and Neurological & Neuromuscular Disease. The MD-Paedigree infostructure integrates the models with: knowledge discovery tools, semantic data representation, and integration and outcome analysis.